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The most powerful weight-loss medication you can legally access is tirzepatide and its 20.2% average is not a consolation prize

Eardley, I., et al

7 A meta-analysis of outcomes data from completed cardiovascular outcome trials suggests that, apart from saxagliptin, DPP-4 inhibitors have a neutral effect on the risk of cardiovascular death, myocardial infarction, stroke and hospitalisation for heart failure

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This medication is also a GLP-1 agonist and is prescribed for many of the same conditions as semaglutide